Question Of The Day

What is toxic oil syndrome? Toxic oil syndrome occurred in Spain in 1981 and affected more than 19000 people. It is characterized by pneumonitis, eosinophilia, pulmonary hypertension and scleroderma like features. The exact etiology remains elusive. Rapeseed oil denatured with 2% aniline was thought to…

Name the chemotherapeutic agent that the patient is receiving in the below PDF. Click here to view PDF! Bleomycin. Bleomycin-induced flagellate erythema is a rare rash associated with the use of this drug. It has a characteristic intermingled lacy appearance. Changal KH et al. Bleomycin-induced…

Several patient specific factors can impact the reliability and accuracy of a pulse oximetry reading. Which patient population is most impacted by this lack of reliability and accuracy? Patients in racial and ethnic minority groups, particularly Black patients, are most impacted by the unreliability and…

What is the reported incidence of ifosfamide encephalopathy? 10-30% has been the reported range of incidence of ifosfamide encephalopathy. In a retorspectie review of 237 patients by David KA et al., the prevalence of ifosfamide encephalopathy was 16%. David KA. Evaluating Risk factors for the…

What is the proposed mechanism of ifosfamide encephalopathy? The exact mechanism is not fully elucidated however it is believed that one of the metabolites, chloracetaledehyde, is the causative agent of ifosfamide induced encephalopathy. David KA. Evaluating Risk factors for the Development of Ifosfamide Encephalopathy. Am…

In an attempt to identify which patients may be at higher risk for developing trichloroethylene hypersensitivity syndrome, miRNAs were evaluated to assess disease susceptibility. Which miRNAs were associated with occupational THS? As discussed in yesterday’s QOD, THS has a significant case fatality rate and the…

Tricholoroethylene hypersensitivity syndrome (THS) has widespread effects including multisystem organ failure. What is the reported case fatality rate? Kamihima M et al. report Occupational trichloroethylene exposures resulting in THS in a subset of patients. The case fatality rate was 9-13%. Kamijima M, Hisanaga N, Wang…

Which indicators predict ADH failure in patients with ethylene glycol poisoning treated without extracorporeal treatment? In a recent systematic review by Beaulieu J et al., 96 articles yielding 411 cases, the ethylene glycol dose, adverse outcomes and treatment failures from EG poisoning were mostly described…

In a recent publication, this novel ‘nitazene’ was recently identified in 3 patients at a single site over a three day period. Calello DP et al. recently reported 3 cases in a 3 day period of N-piperidinyl etonitazene. This novel nitazene had not yet been…