Question Of The Day

This is the base structure of this class of drugs? Benzimidazole. (Other name: Nitazenes). Small structural modifications at the R-groups produce a series of analogous structures such as isotonitazene, etonitazene and metonitazene, just to name a few. https://en.wikipedia.org/wiki/List_of_benzimidazole_opioids

In a recent study in 414 patients with caustic ingestion, what were independent predictors of survival? Assalino M et al. evaluated the outcomes of 414 patients between 2013-2019 with caustic ingestions particularly evaluating the role of CT versus endoscopy. In a multivariate analysis, intentional ingestion,…

In a recent study of therapeutic APAP dosing looking at protein adduct formation, what was the major difference between females and males? Arnold CG et al. performed a secondary analysis in subjects receiving 4 grams APAP daily for greater than or equal to 16 days…

In a prospective study from 2018 comparing low dose versus standard dose CT scan in body stuffers, what was the outcome? This study found that low dose CT scans were able to detect 100% of baggies that were larger than 1cm. Because of the small…

In a review article from 2019, a treatment algorithm was developed for the management of body stuffers; What role, if any, does whole bowel irrigation play in the management of these patients? According to the algorithm, there is no role for whole bowel irrigation and…

In a cohort study of 132 body packers and stuffers what was concluded about the average length of stay? Length of say on average is 2 days before complete elimination of the drug packages. Heymann-Maier L, Trueb L, Schmidt S, Carron PN, Hugli O, Heymann…

In the observational prospective study titled “Complications and hospital stay after endoscopic retrieval of drug baggies in body stuffers: an observational prospective study” what was the most frequent drug encountered in the conservative group? Methamphetamine Shabani M, Kefayati M, Hassanian-Moghaddam H, Zamani N, McDonald R….

Tetramethylammonium hydroxide (TMAH) is a cholinergic agonist that can cause rapid respiratory failure and death. What are the industrial uses of TMAH? TMAH is a chemical used to etch silicon in the development of electronic devices. Previous industrial exposures to high concentration products (25%) have…

Dermal exposure to tetramethylammonium hydroxide (TMAH) can lead to rapid respiratory failure and death. What factors associated with dermal exposure increase this risk? Cases in which patients are exposed to higher concentration products (25% TMAH), when larger body surface areas are exposed, or when patients…

This substance has been blamed for the harmful effects of absinthe? Wormwood. Wormwood oil’s toxicity relates to the active ingredient, thujone. It is speculated the Vincent Van Gogh suffered distorted perceptions and behavioral abnormalities due to chronic absinthe-drinking. Woolf A. Essential Oil Poisoning. Clin Tox…