Question Of The Day

In a recent report of 30 patients with levamisol induced vasculitis, what laboratory abnormalities were noted on CBC? In a report of 30 patients with levamisole cocaine induced vasculitis, anemia was found in 73% of patients, lymphopenia in 70% and leukopenia in 28%. Munoz-Vahos CH…

What does Skin biopsy of patients with levamisole induced vasculitis show? In a report of 30 patients with levamisole cocaine induced vasculitis, skin biopsy was performed in 21 patients. Leukocytoclastic vasculitis was present in 24% followed by pseudovasculitis in 19% and thrombotic vasculopathy with leukocytclastic…

Nitrous oxide irreversibly oxidizes the central cobalt moiety of B12 rendering it nonfunctional. What does this result in? Elevations in homocysteine and methylmalonic acid. Temple C et al. Nitrous oxide abuse induced subacute combined degeneration despite patient initiated B12 supplementation. Clin Tox. 2021; 872-875. doi/full/10.1080/15563650.2022.2046772

Name the two activated forms of B-12. Methylcobalamin and Adenosylcobolamin. Temple C et al. Nitrous oxide abuse induced subacute combined degeneration despite patient initiated B12 supplementation. Clin Tox. 2021; 872-875. doi/full/10.1080/15563650.2022.2046772

Name a cause of pseudohypertriglyceridaemia? Glycerol. Coulson L et al. reported a recent case of severe glycerol intoxication resulting in a profoundly elevated osmolar gap, marked pesudohypertriglyceridaemia and status epilepticus. The most commonly used triglyceride assays measure glycerol. Coulson L et al. Severe glycerol intoxication…

Which Lepiota species of mushrooms contain cyclopeptides? Lepiota helveola, Lepiota josserandi, Lepiota brunneoincarnata. Goldfrank LR. Mushrooms. In: Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS. eds. Goldfrank’s Toxicologic Emergencies, 11e. McGraw Hill; 2019. Accessed August 29, 2022. https://accessemergencymedicine.mhmedical.com/content.aspx?bookid=2569&sectionid=210276854

Which Galerina species of mushrooms contain cyclopeptides? Galerina autumnalis, Galerina marginata, Galerina venenata. Goldfrank LR. Mushrooms. In: Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS. eds. Goldfrank’s Toxicologic Emergencies, 11e. McGraw Hill; 2019. Accessed August 29, 2022. https://accessemergencymedicine.mhmedical.com/content.aspx?bookid=2569&sectionid=210276854

Which Amanita species of mushrooms contain cyclopeptides? Amanita phalloides, Amanita virosa, Amanita bisporigera, Amanita ocreata, Amanita verna. Olson KR. MUSHROOMS, AMATOXIN-TYPE. In: Olson KR, Smollin CG, Anderson IB, Benowitz NL, Blanc PD, Kim-Katz SY, Lewis JC, Wu AB. eds. Poisoning & Drug Overdose, 8e. McGraw…

What is the proposed mechanism for combining bupropion and dextromethorphan for treating depression? The bupropion serves to increase dextromethorphan concentrations through inhibition of its metabolism. In a 6 week, randomized, double blind trial, dextromethorphan-bupropion was associated with reduced Montgomery-Asberg Depression Rating Scale (MADRS) compared to…

In a rat model, what treatment was shown to reduce neuropathic pain from paclitaxel? Melatonin. McCormick et al. administered various doses of melatonin to rats given paclitaxel. Melatonin 10 mg/kg/day was the most effective. McCormick B et al. Melatonin as a potential treatment for paclitaxel…