Question of the Day – Thursday September 17, 2020

What thromboelastogram (TEG) value improved approximately 2-5 hours prior to recovery of fibrinogen concentrations after antivenom administration in a case report of severe Crotalus adamanteus (Eastern Diamondback) envenomation?   Alpha angle which measures speed of fibrin build-up and cross-linking. The authors suggested potential benefit in…

Read More...

Question of the Day – Wednesday September 16, 2020

What enzyme is used in the production of Crotalidae Immune Fab’2 (Equine) antivenom?   Pepsin removes the Fc portion of the antibody leaving two fragment antigen-binding (Fab) portions connected by disulfide bonds. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a16596a5-e87e-40c2-8e34-cea5839849c3

Read More...

Question of the Day – Tuesday September 15, 2020

What enzyme is used in the production of Crotalidae Polyvalent Immune Fab (Ovine) antivenom?   Papain cleaves antibodies leaving solely the fragment antigen-binding (Fab) segment. Caution is advised in patients with documented allergies to papain, chymopapain, or bromelain (from pineapple) due to the risk of…

Read More...

Question of the Day – Monday September 14, 2020

What is the mechanism of the venom for the snake pictured above?   Eastern Coral Snake venom is an alpha-neurotoxin which inhibits acetylcholine at the nicotinic receptors of the neuromuscular junction causing descending muscle weakness/paralysis. https://en.wikipedia.org/wiki/Coral_snake; https://www.ncbi.nlm.nih.gov/books/NBK519031/

Read More...

Question of the Day – Friday September 11, 2020

Which North American snake pictured above (left or right) is venomous?   Right. North American pit vipers have a single row of subcaudal scales below the anal plate in contrast to a divided row in non-venomous snakes. http://www.kentuckyupclose.com/Venomous%20or%20Non-Venomous.html

Read More...

Question of the Day – Thursday September 10, 2020

The venoms of which snakes are used in the production of Crotalidae Immune Fab’2 (Equine) antivenom?   Bothrops asper (fer-de-lance) and Crotalus durissus (tropical rattlesnake). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a16596a5-e87e-40c2-8e34-cea5839849c3

Read More...

Question of the Day – Wednesday September 9, 2020

The venoms of which snakes are used in the production of Crotalidae Polyvalent Immune Fab (Ovine) antivenom?   Crotalus atrox (Western Diamondback rattlesnake), Crotalus adamanteus (Eastern Diamondback rattlesnake), Crotalus scutulatus (Mojave rattlesnake), and Agkistrodon piscivorus (Cottonmouth or Water Moccasin). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=77abd784-3387-420d-abdc-4fe97215d233

Read More...

Question of the Day – Tuesday September 8, 2020

“Miracle Mineral Solution” has recently been touted as a prevention and cure for COVID-19 despite several warnings from the FDA. This product contains what chemical and what is the toxicity?   Miracle Mineral Solution contains 28% sodium chlorite in distilled water. The product often comes…

Read More...

Question of the Day – Friday September 4, 2020

This is a 26 year old male that presented with these findings. He says that this happened after being out in the sun. What is his occupation?   Abugroun A et al reported this case of lime-induced phytophotodermatitis in a 26 year old male bartender….

Read More...

Question of the Day – Thursday September 3, 2020

In a recent case report, canagliflozin is suspected to be the culprit of rosuvastatin myotoxicity. What is the theorized mechanism of this potential drug interaction?   In a recent case report, it is theorized that canagliflozin enhanced the absorption of rosuvastatin and inhibited both biliary…

Read More...

Site Search