Question of the Day

Question: As part of their risk management strategy for certain drugs, the Food and Drug Administration (FDA) requires a so-called “Risk Evaluation and Mitigation Strategy (REMS)”. What does a REMS include?

Question: The concentration of melanin in human hair is recognized as affecting the amount of some drugs that might be incorporated into hair. As a consequence, at co-equal doses, higher drug levels are typically found in the hair of individuals with darker colored hair. This influence is particularly pronounced for which class of drugs?

Question: One population-based cohort study of older adults, observed that new use of an atypical antipsychotic drug was associated with a higher 90-day risk for hospitalization with acute kidney injury (AKI). What are the potential causes for this observed effect?

Question: A recent analysis of counterfeit OxyContin seized in Canada demonstrated fentanyl to be present in 89% of all tablets. Fentanyl is also often found in counterfeit alprazolam as well as other counterfeit medications. Why is fentanyl apparently used so often in the production of…

Question: A recent analysis of counterfeit OxyContin seized in Canada demonstrated fentanyl to be present in 89% of all tablets. Fentanyl is also often found in counterfeit alprazolam as well as other counterfeit medications. Why is fentanyl apparently used so often in the production of illicit street drugs?

Question: What is the “exposome”?

Question: What are the clinical characteristics associated with acute clonidine overdose?

Question: A strong association between which anticonvulsant drug and the HLA-B*1502 allele has been found in Asian populations suffering from Stevens-Johnson syndrome (SJS) and the related disorder toxic epidermal necrolysis (TEN).

Question: Which two drugs are considered to be associated with the highest risk for the development of drug-induced lupus (DIL)?

Question: What is a cancer “cluster” and how many purported “cancer clusters" are reported to state health departments each year?

Question: What is the relative potency of the drug carfentanyl in relation to morphine and fentanyl?