Question: Which two drugs are considered to be associated with the highest risk for the development of drug-induced lupus (DIL)?
Answer: The cited reference notes “Procainamide, with a DIL incidence during 1 year of therapy of approximately 20% and hydralazine, with a 1- year incidence of 5-8% are by far the highest risk drugs for inducing lupus-like disease…” (Rubin RL. Drug-induced lupus. 2015 Expert Opin Drug Saf 14(3):361-378)
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