Question: One population-based cohort study of older adults, observed that new use of an atypical antipsychotic drug was associated with a higher 90-day risk for hospitalization with acute kidney injury (AKI). What are the potential causes for this observed effect?
Answer: The cited reference notes “Drug use was also associated with an increased risk for other adverse outcomes, including hypotension, acute urinary retention, pneumonia, and acute cardiac events. These outcomes are known potential causes of AKI.” (Hwamng YJ et al. Atypical antipsychotic drugs and the risk for acute kidney injury and other adverse outcomes in older adults: a population-based cohort study. 2014 Ann Intern Med. 161:242-248)