Question: A strong association between which anticonvulsant drug and the HLA-B*1502 allele has been found in Asian populations suffering from Stevens-Johnson syndrome (SJS) and the related disorder toxic epidermal necrolysis (TEN).
Answer: The cited article notes “A strong association between HLA-B*1502 and carbamazepine-induced SJS-TEN has been found in Asian populations other than the Han Chinese, including Malay, Thai, and South Asian Indians. In Malaysia, Thailand, and India studies have shown that carbamazepine as the major cause of drug induced SJS-TEN.” (Chen P et al. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. 2011 NEJM 364:1126-1133)
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