Question of the Day

Question of the Day – Friday February 8, 2019

Question – The article cited below notes that xylazine “is marketed as a veterinary drug and used as a sedative, analgesic and muscle relaxant. In humans, it could cause central nervous system depression, respiratory depression, bradycardia, hypotension, and even death.” This substance has been used to adulterate a variety of street drugs including heroin and cocaine. What is the mechanism of action of xylazine?

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Question of the Day – Thursday February 7, 2019

Question – The reference cited below notes between the years 1992 and 1998, “several patients in the U.S. Pacific Northwest developed anorexia, malaise, nausea, vomiting, abdominal cramping, diarrhea, diaphoresis, and vertigo within 30 mins to 12 hrs of consuming a particular raw or cooked mushroom”. Reportedly, many of the poisoned patients were seeking the edible white matsutake mushroom, Tricholoma magnivalere. What mushroom species was responsible for this outbreak of mushroom related illness?

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Question of the Day – Wednesday January 30, 2019

Question – Adamsite (diphenylaminechlorarsine) is a vomiting compound that has been used as a riot-control agent (military designation, DM). Adverse health effects due to exposure to adamsite involve rapid onset irritation of the eyes, upper airway, and skin and also nausea and vomiting. If concentrations are low, initial symptoms may resemble those of a severe cold. What is the usual time course of effects related to adamsite exposure?

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