Question of the Day – Friday March 19, 2021
What is the dosing and frequency of clonazepam that has been reported to be efficacious in cessation of alprazolam without significant withdrawal symptoms? Substitution of clonazepam for alprazolam at a mg per mg dose divided twice daily, with a 1 to 1.5 mg daily reduction every…
Question of the Day – Thursday March 18, 2021
What findings have been associated with neonatal venlafaxine discontinuation syndrome? poor feeding, jitteriness, respiratory distress, and myoclonic seizure-like activity have been reported. Holland J, Brown R. Neonatal venlafaxine discontinuation syndrome: A mini-review. Eur J Paediatr Neurol. 2017 Mar;21(2):264-268. doi: 10.1016/j.ejpn.2016.11.003. Epub 2016 Nov 25. PMID:…
Question of the Day – Wednesday March 17, 2021
What is the proposed mechanism for false positive enzymatic ethanol assay results? Enyzmatic ethanol assays measure the production of NADH from NAD+ which is formed at the same molar per molar ratio of ethanol to acetylaldehyde. Lactate is metabolized to pyruvate with the same molar…
Question of the Day – Tuesday March 16, 2021
What are the most common immune related adverse events from Immune Checkpoint Inhibitors (ICIs)? Dermatologic skin findings are the most common presentatio of immune related adverse events from ICIs. Most immune related adverse events occur within 3 – 6 weeks of starting therapy with the…
Question of the Day – Monday March 15, 2021
What is the antidote for a patient with severe cytokine release syndrome (CRS) after treatment with CAR-T? Tocilizumab. It is a humanized monoclonal antibody that competitively inhibits binding of IL-6 to its receptor. It is indicated for any CRS grade above 2. CARTOX is a…
Question of the Day – Friday March 12, 2021
Name 3 CAR-T products that are currently approved by the FDA ? Tisagenlecleucel for patients 25 years and younger with refractory ALL AND for adults with relapses/refractory diffuse large b-cell lymphoma; Axicabtagene ciloleucel for adult patients with diffuse large b-cell lymphoma; Brexucabtagene autoleucel for adults…
Question of the Day – Thursday March 11, 2021
Toxicity with which substance is responsible for causing “gasping syndrome” in neonates? Benzyl Alcohol. Benzyl alcohol is an aromatic alcohol that is oxidized to benzoic acid, conjugated in the liver with glycine, and excreted in the urine as hippuric acid. This process required for the…
Question of the Day – Wednesday March 10, 2021
A 34 week-gestation infant was delivered from a mother with bipolar disease and PTSD on a combination of venlafaxine 150 mg daily, bupropion hydrochloride 300 mg daily, quetiapine 200 mg daily, and gabapentin 1200 mg 3 times daily. What symptoms did the infant experience and…
Question of the Day – Tuesday March 9, 2021
In a cohort of overdose patients admitted to two hospitals in northwestern France in the past decade, the authors compared survival among critically ill patients with and without extracorporeal life support (ECLS). How many of the patients with persistent cardiac arrest survived without ECLS? 0%….
Question of the Day – Monday March 8, 2021
A recent study of non-fatal drug-related overdoses in youths reported from the CDC’s National Syndromic Surveillance System Biosense Program from 2016 to 2019 showed what trends for heroin and stimulants? Suspected heroin overdoses decreased by an average of 3.3% per quarter for youth aged 15…