What is the dosing and frequency of clonazepam that has been reported to be efficacious in cessation of alprazolam without significant withdrawal symptoms?
Substitution of clonazepam for alprazolam at a mg per mg dose divided twice daily, with a 1 to 1.5 mg daily reduction every 2 days resulted in successfull cessation of alprazolam within 7 to 10 days in 37 patients. 20 of these patients were managed as outpatients.
Patterson JF. Withdrawal from alprazolam dependency using clonazepam: clinical observations. J Clin Psychiatry. 1990 May;51 Suppl:47-9; discussion 50-3. PMID: 2335501.
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