Question Of The Day

In a recent retrospective review of ciguatera poisoning reported to the French Poison Control Centers, 91% of patients with ciguatera poisoning after consuming fish from the Atlantic Ocean had nausea, vomiting, diarrhea and abdominal pain as their first symptoms. This was vastly different if the…

Increased occupational exposure to styrene increases the concentration of this metabolite found in the urine?   A recent study in 53 plastic injection workers by Mohamadyan M et al. revealed that increased occupational exposure to styrene increased mandelic acid concentrations in the urine. Mohamadyan M…

The spur winged goose holds this toxin within its tissue?   The spur winged goose has a diet that includes ingestion of blister beetles. Cantharidin is held within the tissue of the fowl and can result in poisoning if ingested. Wikipedia. https://en.wikipedia.org/wiki/Spur-winged_goose. Accessed 24 June 2020

A recent study suggests that B-oxidation inhibition may play a role in initiation of hepatotoxicity after this commonly used xenobiotic?   Ganetsky M et al. performed a metabolomic analysis of acetaminophen induced subclinical liver injury to attempt to determine the role of 2E1 inhibition on…

“ZaZa” and “Tianna Red” are common names for this substance that has recently increased in use in the US?   Tianeptine is an antidepressant approved in some European countries with the trade names of Coaxil or Stablon. Over the past several years, tianeptine misuse and…

This laboratory finding was associated with deficits in episodic memory dysfunction in patients with acute organophosphate poisoning?   Complete RBC-AChE inhibition, compared to partial inhibition, was associated with deficits in episodic memory in patients that had acute organophosphate poisoning. These patients had poorer episodic memory…

This mitochondrial uncoupler recently was shown to reverse obesity and insulin resistance in mice.   BAM15 is a mitochondrial uncoupler, structurally unrelated to dinitrophenol, and in a recent mouse model was shown to be orally bioavailable and decreased body fat mass. In this model and…

Performance and image enhancing drugs (“PIED”) are increasingly available and easily accessible online and on the black market. A recent analysis analyzed 400 products from samples confiscated in Italy over a 2 year period. What was the percentage of substances that had a qualitative analysis…

In a recent retrospective analysis of fatal iatrogenic therapeutic errors reported to National Poison Data System, this group of drugs was responsible for the most number of cases?   In the recent review, specific medications were known in 171 out of 172 cases with cardiac…

The FDA recently sent out an alert about a potential drug interaction with remdesivir and this drug?   On June 15, 2020 the Food and Drug Administration issued an alert about a potential drug interaction between remdesivir and hydroxychloroquine. The interaction may result in reduced…