Question- Acetaminophen toxicity in pregnancy is not a common condition with few cases of associated detrimental fetal effects noted in the literature. What is the incidence of fetal compromise associated with acetaminophen exposures at 27 weeks (or greater) of gestation?
Answer- The cited article notes “For exposures at 27 weeks of gestation or greater, the incidence of fetal compromise (non-reassuring fetal status necessitating delivery or stillbirth) was 5%, and all adverse outcomes occurred within 6 days of acetaminophen ingestion. Once a pregnant woman is outside the window of 6 days after ingestion without signs of worsening liver function, the chance of adverse neonatal outcome seems to be low and most reports show women carrying to term and delivering healthy neonates.” (Taney J et al. Placental abruption with delayed fetal compromise in maternal acetaminophen toxicity. 2017 Obstet Gynecol 130:159-162)