What is Gulran Disease?
Gulran Disease refers to poisoning from pyrrolizidine alkaloids (primarily heliotrine) from consuming bread made from wheat contaminated with Heliotropium spp. Gulran refers to the Gulran district of Herat Province.
Kakar F, Akbarian Z, Leslie T, Mustafa ML, Watson J, van Egmond HP, Omar MF, Mofleh J. An outbreak of hepatic veno-occlusive disease in Western afghanistan associated with exposure to wheat flour contaminated with pyrrolizidine alkaloids. J Toxicol. 2010;2010:313280. doi: 10.1155/2010/313280. Epub 2010 Jun 28. PMID: 20652038; PMCID: PMC2905904.
Contributed by Michael Keenan, MD
Posted in Question Of The Day