Question of the Day

Question -What is the pathophysiology of cocaine-induced acute aortic dissection?

Question - Campylobacteriosis is the most common bacterial cause of diarrheal illness in the United States and caused by the bacteria Campylobacter. This disease often results from drinking water. Where and how does Campylobacter get into drinking water?

*Note: There was a typo in the answer from the QOD for March 4, 2019. It has been corrected on the website for viewing. Our apologies*

Question - Electronic vapor products (EVPs) comprise a diverse group of devices, including electronic cigarettes (e-cigarettes). EVP users inhale an aerosol that typically contains nicotine, flavorings, and other additives. Nicotine is a developmental toxicant that adversely affects pregnancy and infant outcomes. What percent of females report using e-cigarettes at any point around the time of pregnancy or during the last 3 months of pregnancy?

Question - Some have commented on a characteristic odor exuded by individuals who have recently used PCP. How is that odor described and what is the basis for that odor?

Question - The article cited below reports: “Drug induced dystonia is a movement disorder usually observed within a few hours of a single dose, especially after parenteral administration, but may appear after a delay of several hours to a few days.” What are the patient risk factors that may predispose to the development of dystonia?

Question - Why is abstinence not necessary prior to the initiation of methadone therapy for opiate abuse disorder?

Question - Fluoroquinolones have been recognized as causing serious adverse effects including tendinopathies, tendon rupture, aortic rupture and aortic tears. What is the probable mechanism for these effects?

Question - With regard to the treatment of long acting anticoagulant rodenticide (LAAR) poisoning, the addition of what drug to the treatment regimen has been advocated in order to increase hepatic elimination via increased microsomal activity?

Question - NSAIDs (primarily ibuprofen, but also naproxen, diclofenac and sulindac as well) are the main class of drugs implicated as causing drug induced aseptic meningitis. What groups of patients have increased risk for the development of NSAID-induced aseptic meningitis?

Question - Methotrexate administered to pediatric patients, including infants and adolescents, may result in long-term cognitive impairments (including memory impairment, attention and executive function deficits). What percentage of survivors of childhood leukemia treated with methotrexate will experience result in long-term cognitive impairments?