Question - NSAIDs (primarily ibuprofen, but also naproxen, diclofenac and sulindac as well) are the main class of drugs implicated as causing drug induced aseptic meningitis. What groups of patients have increased risk for the development of NSAID-induced aseptic meningitis?
Answer- The cited article notes “Interestingly, there seems to be an additional risk of developing an NSAID-induced aseptic meningitis in patients with autoimmune disease such as SLE, Sjogren syndrome, or mixed connective tissue disease. As a matter of fact, autoimmune diseases are predisposing factors for aseptic meningitis.” (Yelehe-Okouma M et al. Drug induced aseptic meningitis: a mini review. 2018 Fund Clin Pharm 32:252-260)