Question - Fluoroquinolones have been recognized as causing serious adverse effects including tendinopathies, tendon rupture, aortic rupture and aortic tears. What is the probable mechanism for these effects?
Answer- The cited article notes “Fluoroquinolones up-regulate cell matrix metalloproteinases, resulting in a reduction of collagen fibrils of types I and III collagen, which comprise the majority of collagen in both Achilles tendons and the aorta, serving as a likely mechanism for these adverse events.” (Sakouas G. Adverse effects of fluoroquinolones: Where do we stand? 2019 JEJM 380. Online at https://www.jwatch.org/na48248/2019/02/13/adverse-effects-fluoroquinolones-where-do-we-stand?query=jwclinspotnejmbadge)