What was the frequency of precipitated opioid withdrawal when 1.6 mg of IM nalxoone was used to reverse opioid overdose?
In a recent prospective review of 171 patients with opioid overdose in Australia, nearly 40% of patients developed acute precipiated withdrawal when administred 1.6 mg of intramuscular Naloxone, while only 7% experienced severe agitation.
Isoardi KZ, Parker L, Harris K, Rashford S, Isbister GK. Acute Opioid Withdrawal Following Intramuscular Administration of Naloxone 1.6 mg: A Prospective Out-Of-Hospital Series. Ann Emerg Med. 2022 Aug;80(2):120-126. doi: 10.1016/j.annemergmed.2022.03.004. Epub 2022 Apr 29. PMID: 35491292.