Question - Patients taking colchicine may require careful dose monitoring and adjustment when taking which drugs in concert with colchicine?
Answer- The cited review notes “Simultaneous use of colchicine with CYP3A4 inhibitors/competitors, including clarithromycin, many HIV medications, calcium channel blockers and azole antifungals, or with P-gp inhibitors/competitors such as cyclosporin and ranolazine, can lead to accumulation of colchicine, resulting in increased potential for toxicity.” (Slobodnick A et al. Update on colchicine, 2017. 2018 Rheumatology 57: i14-i11)
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