What enzyme inhibitor prevents the insecticidal activity of chlorfenapyr?
Piperonyl butoxide. Activity of chlorfenapyr is related to CYP enzyme metabolism resulting in the generation of a free pyrrole which uncouples oxidative phosphorylation. In humans, it is associated with delayed symptom onset and a high case fatality rate. Use of CYP inhibitors after human exposure has not been investigated.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Holland MG. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellants. In: Goldfranks Toxicologic Emergencies; 11th edition. Chapter 111.