In a recent review of snake envenomation, the authors discussed venom-induced consumption coagulopathy, which causes a depletion of clotting cascade factors and spontaneous or uncontrolled bleeding. What is the most relevant procoagulant toxin?
Metalloproteinases activate prothrombin, factor V, factor X and fibrinogenase.
Seifert S, Armitage JO, Sanchez EE. Snake Envenomation. NEJM 2022;386:68-78.
Submitted by: Kirk Cumpston, DO FAACT on behalf of The Medical Toxicology Fellowship, Virginia Commonwealth University