Historical QOD 12/11/08: What abnormalities have been associated with the use of fenfluramine-phentramine?
Valvular heart disease. In 1997, researchers at the Mayo Clinic presented a report on 24 patients who developed valvular insufficiency while taking the combination diet pill Fen-phen. The mitral valve was the most commonly affected valve, followed by the aortic valve. Patients with left sided valve dysfunction developed pulmonary hypertension.
Graham DJ, Green L. Further cases of valvular heart disease associated with fenfluramine-phentermine. N Engl J Med. 1997 Aug 28;337(9):635. doi: 10.1056/NEJM199708283370911. PMID: 9280830.
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