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June 26, 2019

Question of the Day – Wednesday June 26, 2019

Question - Capsaicin, the active ingredient in chili peppers, has been used as a local treatment for pain. What is the mechanism of action of capsaicin with regard to the treatment of local pain?

Answer- The cited article notes “Capsaicin, which is the active pungent ingredient in chili peppers, activates the transient receptor potential vanilloid channel of small peripheral sensory nerves. The effect of repeated applications or of a single high-dose application is thought to occur through desensitization and a temporary reduction in the number of pain fibers in the skin. (Finnerup NB. Nonnarcotic methods of pain management. 2019 NEJM380:2440-2448)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
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      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
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