In a recent study of single substance exposures to hydroxyzine and diphenhydramine, which agent was less likely to result in antimuscarinic symptoms?
In a recent review of single substance exposures to hydroxyzine and diphenhydramine reported to the National Poison Data System (NPDS) and Toxicologic Investigators Consortium (ToxIC) registry, hydroxyzine-poisoned patients were less likely to manifest antimuscarinic symptoms. They were also less likely to receive physostigmine.
Simon M, Heard K. Are antimuscarinic effects common in hydroxyzine overdose? A cohort analysis of antimuscarinic effects in hydroxyzine and diphenhydramine-poisoned patients. Clinical Toxicology. 2023;61(5):379-386. doi:10.1080/15563650.2023.2200575
Contributed by Kristin Reinaker, PharmD, DABAT on behalf of Sarah Thomas, PharmD candidate 2024