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The American Academy of Clinical Toxicology
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July 14, 2021

Question of the Day – Wednesday July 14, 2021

What is the most common immune-related adverse event (irAE) from immune checkpoint inhibitors to result in discontinuation of therapy or death?

Dermatologic manifestations are the most common irAE’s however, pneumonitis is the most common adverse event to result in drug discontinuation or death.

Lipe DN, Shafer S. CAR-T and checkpoint inhibitors: toxicities and antidotes in the emergency department. Clin Toxicol (Phila). 2021 May;59(5):376-385. doi: 10.1080/15563650.2021.1880008. Epub 2021 Feb 12. PMID: 33576256

Submitted by: Brandon Wills, DO on behalf of The Medical Toxicology Fellowship, Virginia Commonwealth University

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • Meeting Information
    • Abstract Submissions
    • After the Fact CE
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