What is the most common immune-related adverse event (irAE) from immune checkpoint inhibitors to result in discontinuation of therapy or death?
Dermatologic manifestations are the most common irAE’s however, pneumonitis is the most common adverse event to result in drug discontinuation or death.
Lipe DN, Shafer S. CAR-T and checkpoint inhibitors: toxicities and antidotes in the emergency department. Clin Toxicol (Phila). 2021 May;59(5):376-385. doi: 10.1080/15563650.2021.1880008. Epub 2021 Feb 12. PMID: 33576256
Submitted by: Brandon Wills, DO on behalf of The Medical Toxicology Fellowship, Virginia Commonwealth University