Question - An outbreak of sub-acute myelo-optic neuropathy syndrome (SMON) occurred in Japan during the 1950s. What drug was found to be responsible for this outbreak?
Answer - The drug clioquinol was responsible for an outbreak of sub-acute myelo-optic neuropathy syndrome (SMON) occurred in Japan during the 1950s. (Hanakago R and Uono M. Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan. 1981 Clin Tox 18(12): 1427-1434)
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