What solvents are associated with dying back peripheral neuropathy?
N-hexane and methyl n-butyl ketone. Axonal destruction results from the metabolite, 2,5-hexanedione, and starts in a stocking-glove distribution.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Chang YC. Neurotoxic effects of n-hexane on the human central nervous system: evoked potential abnormalities in n-hexane polyneuropathy. J Neurol Neurosurg Psychiatry 1987;50(3):269-74. doi: 10.1136/jnnp.50.3.269.
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