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February 19, 2020

Question of the Day – Wednesday February 19, 2020

Okadaic acid (OA) and dinophysistoxin (DTX) are toxins produced by dinoflagellates in the genera Dinophysis and Prorocentrum. What is the associated toxicity in humans and the mechanism of action of the toxin(s)?

OA and DTX exposure from edible seafood results in rapid onset of diarrhea, nausea, vomiting, and abdominal pain. The reported mechanism of action is inhibition of protein phosphatases (PP2a, PP5, and PP1). (Twiner, Michael, et al. “Structure–Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins.” Marine Drugs, vol. 14, no. 11, 2016, p. 207., doi:10.3390/md14110207.)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
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      • ABAT Member Directory
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      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
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      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
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    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
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