What is the mechanism of mamba (Dendroaspis spp.) venom toxicity?
α-neurotoxins block postsynaptic nicotinic receptors at the neuromuscular junction, dendrotoxins inhibit voltage-dependent potassium channels which releases acetylcholine at the neuromuscular junction causing a depolarizing effect, fasciculins act as acetylcholinesterase inhibitors, and calciseptine inhibits L-type calcium channels.
Quarch V, et al. An Unexpected Case of Black Mamba (Dendroaspis polylepis) Bite in Switzerland. Case Rep Crit Care 2017; doi: 10.1155/2017/5021924