Question - What is the only topical retinoid that has been designated as pregnancy category X (i.e. a teratogen that should never be used in pregnant or lactating women)?
Answer - The cited article notes “Tazarotene is the only topical retinoid that has been designated as pregnancy category X (indicating that it is a teratogen that should never be used in pregnant or lactating women), on the basis of its dual indication for psoriasis with the potential for use over a greater body-surface area. Therefore, contraceptive counseling is important for all women of childbearing potential who use this medication.” (Zaenglein AL. Acne Vulgaris. 2018 NEJM 379:1343-1352)
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