What is the mechanism of quinine-induced hemolytic-uremic syndrome (HUS)?
According to the cited reference, the likely mechanism by which quinine induces HUS is via quinine-dependent antibodies to blood cellular constituents. These antibodies likely cause endothelial damage and the resultant nephropathy, microangiopathic hemolytic anemia, and thrombocytopenia that define HUS.
Crum NF, Gable P. Quinine-induced hemolytic-uremic syndrome. South Med J. 2000 Jul;93(7):726-8. PMID: 10923967.