What is the proposed mechanism of action for polymixin B in cyclopeptide mushroom poisoning?
Binding to RNA polymerase II, preventing a-Amanitin binding and inhibition of protein synthesis. The suggested dose of 0.75 mg/kg (7,500 units/kg) is lower than typical doses used for antibiosis and is not expected to contribute to nephrotoxicity.
Goldfrank LR. Mushrooms. In: Nelson LS, Howland M, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS. eds. Goldfrank’s Toxicologic Emergencies, 11e. McGraw Hill; 2019. Accessed August 29, 2022. https://accessemergencymedicine.mhmedical.com/content.aspx?bookid=2569§ionid=210276854
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