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November 9, 2021

Question of the Day – Tuesday November 9, 2021

n-hexane and methyl n-butyl ketone are peripheral neurotoxins due to this common metabolic intermediate?

The common metabolite that cause peripheral neurotoxicity from n-hexane and methyl n-butyl ketone is 2,5-hexanedione.

Spencer PS, Chen X. The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin. Toxics. 2021;9(5):98. Published 2021 Apr 29. doi:10.3390/toxics9050098

Bos PM, de Mik G, Bragt PC. Critical review of the toxicity of methyl n-butyl ketone: risk from occupational exposure. Am J Ind Med. 1991;20(2):175-194. doi:10.1002/ajim.4700200205

Couri D, Milks M. Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione. Annu Rev Pharmacol Toxicol. 1982;22:145-166. doi:10.1146/annurev.pa.22.040182.001045

Submitted by: Natasha Tobarran, DO on behalf of The Medical Toxicology Fellowship Virginia Commonwealth University

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
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      • ABAT Travel Grants
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        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Advisory Board Contact Information
    • Advanced Hazmat Life Support Training (AHLS)
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    • ClinTox E-Learn
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      • AACT Committee Leadership Opportunities
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