Question - The administration of L-carnitine has been recommended by some as an adjunctive therapy for valproic acid overdose. What are the ingested doses and resultant blood levels of valproic acid that have been recommended for L-carnitine administration?
Answer - The cited article notes that the administration of L-carnitine is usually reserved for ingestions greater than 400 mg/kg and/or measured blood levels in excess of 450 mg/L. (Muniz AE. Valproic acid overdose review if a case with electrocardiographic changes. 2017 J Emerg Med 53(3): 333-338)
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