How does CYP2E1 contribute to ethanol-induced hepatitis?
CYP2E1, a major enzyme in the metabolism of ethanol, is induced in chronic ethanol consumption. CYP2E1 then significantly contributes to the oxidation of ethanol to acetaldehyde, but produces reactive oxygen species concurrently. In chronic ethanol consumption, the generation of reactive oxygen species overcomes the capacity of the liver to remove them with antioxidants. The buildup of these reactive oxygen species then causes oxidative stress to liver cells.
Osna NA et al. Alcoholic Liver Disease: Pathogenesis and Current Management. Alcohol Res 2017; 38(2): 147-161. PMID: PMC5513682
Submitted by: Abigail Sharpe, PharmD on behalf of Acute and Intensive Care Section