Question- What characterizes the cardiac effects seen in flecainide toxicity?
Answer- The cited reference notes “In flecainide overdose, the adverse effects are mainly due to excess cardiac sodium channel blockade causing delayed conduction, negative inotropy, and cardiac dysrhythmias, including bradyarrhythmias, AV nodal block, ventricular tachycardia/fibrillation, and asystole.” (Valentino MA et al. Flecainide toxicity: A case report and systematic review of its electrocardiographic patterns and management. 2017 Cardiovasc Toxicol 17:260-266)
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