What agents may be helpful in the treatment of methotrexate mediated neurotoxicity.
Dextromethorphan and methylxanthines.
1. Fernandez-Fernandex FJ et al. Dextromethorphan and methylxanthines might be useful in the treatment of methotrexate induced neurotoxicity. Pediatric Emerg Care 2017; 33(5): 380.
2. Drachtman RA et al. Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatric Hematology and Oncology 2002; 19(5): 319-327.