At a dose of 4 mg oral cyproheptadine TID, what percentage of CNS 5-HT receptors are blocked?
According to the cited reference, at 4 mg TID, cyproheptadine blocks 85% of 5-HT receptors. At a dose of 6 mg TID, an estimated 95% of receptors are blocked. (Kapur, Shitij et al. “Cyproheptadine: a Potent in Vivo Serotonin Antagonist.” American Journal of Psychiatry, vol. 154, no. 6, 1997, doi:10.1176/ajp.154.6.884a.)