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June 12, 2018

Question of the Day – Tuesday June 12, 2018

Question - The reference cited below notes “Long-term inhalation of cannabinoids can be associated with the appearance of symptomatic sinus bradycardia and sinus arrest that can lead to asystole with syncope.” What is the mechanism for this observed effect in some cannabinoid users?

Answer - The cited article reports “Prolonged THC ingestion in human volunteers and mongrel dogs has been associated with the following: parasympathetic dominance that features sinus bradycardia; accentuated reflex bradycardia to exogenous catecholamines; enhanced withdrawal of sympathetic tone; and attenuated circulatory responses to exercise in keeping with centrally mediated enhanced parasympathetic activity and reduced sympathetic activity.” (Heckle MR et al. Cannabinoids and symptomatic bradycardia. 2018 Am J Med Sci 355(1):3-5)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
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      • Radiation
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    • Student Chapters
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