Question - The incidence of neonatal abstinence syndrome (NAS) in the U.S. is currently estimated to be 6.0 per 1000 live births. Following birth when do the symptoms of NAS typically manifest?
Answer - The cited article states “Newborns typically experience signs of withdrawal 2 to 3 days after birth, and infants whose symptoms are severe enough to require pharmacologic intervention are typically treated with replacement opioids such as methadone or morphine, and then weaned off over days to weeks.” (Wachman EM et al. Neonatal abstinence syndrome- Advances in diagnosis and treatment. 2018 JAMA 319(13)1362-1374)