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July 19, 2022

Question of the Day – Tuesday, July 19, 2022

What is the significance of 2-benzylbenzimidazole (“nitazenes”) compared to other synthetic opioids?

2-Benzylbenzimidazole opioids, also termed “nitazenes” are structurally dissimilar to other opioids. These agents are more potent than fentanyl likely yielding signfiicant negative outcomes in patients.

1.Vandeputte MM, Uytfanghe KV, Layle NK, et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of “nitazene” 2-benzylbenzimidazole synthetic opioids. ACS Chem Neurosci. 2021;12(7):1241–1251.

2.Calello DP et al. Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne) in patients with suspected opioid overdose. Clin Tox Published online 16 June 2022. https://doi.org/10.1080/15563650.2022.2084406

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
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    • Student Chapters
  • NACCT Annual Meeting
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