In a blinded, randomized, controlled trial of ketamine versus midazolam and haloperidol for treatment of agitation in the emergency department, what was the reported frequency of laryngospasm in the ketamine arm?
1/40 (2.5%) patients in the ketamine arm demonstrated laryngospasm after 5 mg/kg intramuscular injection
Barbic D, Andolfatto G, Grunau B, Scheuermeyer FX, Macewan B, Qian H, Wong H, Barbic SP, Honer WG. Rapid Agitation Control With Ketamine in the Emergency Department: A Blinded, Randomized Controlled Trial. Ann Emerg Med. 2021 Dec;78(6):788-795. doi: 10.1016/j.annemergmed.2021.05.023. Epub 2021 Aug 2. PMID: 34353650.