What is the maximum daily dosing of Tizanidine and lowest dose that has been associated with coma?
According to the cited reference, the maximum recommended daily dose of tizanidine is 36 mg per day. The lowest dose associated with coma was 60 mg.
Spiller, H. A., Bosse, G. M., & Adamson, L. A. (2004). Retrospective review of Tizanidine (Zanaflex) overdose. Journal of toxicology. Clinical toxicology, 42(5), 593–596. https://doi.org/10.1081/clt-200026978
Contributed by Sarah Sprauer, MD
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