Skip to content
The American Academy of Clinical Toxicology
  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
    • National Clintox Book Club
    • Webinars
  • NACCT Annual Meeting
    • Abstract Submissions
    • Meeting Information
    • Register
    • After the Fact CE
  • Research Grants
    • AACT Research Award
    • AACT Knowledge Translation Grant Award
    • Junior Investigator Research Grant
    • Gary S. Wasserman, DO, FAACT Memorial Pediatric Abstract Award
    • Toxicology Trainee Research Grant
    • Student and Trainee Travel Award
    • Lampe-Kunkel Memorial Award
  • Resources
    • Event Calendar
    • Publications
      • Clinical Toxicology Journal
      • Question of the Day
      • News
      • Current Awareness in Clinical Toxicology
      • Toxicology Today
      • Out of Hospital Guidelines
    • Toxicology Information
    • Affiliated Organizations
    • Press Resources
    • Job Opportunities
    • Online Store
  • About Us
    • Board of Trustees
      • AACT Board of Trustees Nominations
    • Mission & Strategic Plan
    • Bylaws
    • AACT Code of Ethics
    • Our History
    • Fellows of AACT
    • Membership
      • AACT Member Directory
    • Award Recipients
    • Contact Us
  • Contact Us
  • Renew
  • Donate
  • Journal Access
The American Academy of Clinical Toxicology
Member LoginJoinContact
  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
    • National Clintox Book Club
    • Webinars
  • NACCT Annual Meeting
    • Abstract Submissions
    • Meeting Information
    • Register
    • After the Fact CE
  • Research Grants
    • AACT Research Award
    • AACT Knowledge Translation Grant Award
    • Junior Investigator Research Grant
    • Gary S. Wasserman, DO, FAACT Memorial Pediatric Abstract Award
    • Toxicology Trainee Research Grant
    • Student and Trainee Travel Award
    • Lampe-Kunkel Memorial Award
  • Resources
    • Event Calendar
    • Publications
      • Clinical Toxicology Journal
      • Question of the Day
      • News
      • Current Awareness in Clinical Toxicology
      • Toxicology Today
      • Out of Hospital Guidelines
    • Toxicology Information
    • Affiliated Organizations
    • Press Resources
    • Job Opportunities
    • Online Store
  • About Us
    • Board of Trustees
      • AACT Board of Trustees Nominations
    • Mission & Strategic Plan
    • Bylaws
    • AACT Code of Ethics
    • Our History
    • Fellows of AACT
    • Membership
      • AACT Member Directory
    • Award Recipients
    • Contact Us
  • Contact Us
February 14, 2023

Question of the Day – Tuesday, February 14, 2023

In a recent metanalysis of studies examining whether the paracetamol x transferase multiplication product predicted hepatotoxicity after paracetamol overdose, the authors analyzed 5,036 participants as an entire group and as subgroups. This product was particularly helpful in ruling out hepatotoxicity in which presentation: single acute ingestion; staggered ingestion; before eight hours from ingestion, or after eight hours from ingestion?

The lower limit multiplication product of 1,500 mg/L x IU/L in the staggered ingestion, was 100% sensitive at predicting who will eventually develop hepatoxicity.

Chun En Yau, Haoyang Chen, Bryant Po-Yuen Lim, Mingwei Ng, R. Ponampalam, Daniel Yan Zheng Lim, Yip Han Chin & Andrew Fu Wah Ho (2022) Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis, Clinical Toxicology, DOI: 10.1080/15563650.2022.2152350

Posted in Question Of The Day
Share this

Recent Posts

  • Question of the Day – Monday, November 4, 2024
  • Question of the Day – Friday, November 1, 2024
  • Question of the Day – Thursday, October 31, 2024
  • Question of the Day – Wednesday, October 30, 2024
  • Question of the Day – Tuesday, October 29, 2024

Site Search

Get Involved

Volunteer for a committee, as a section chair, student chapter mentor, author Question of the Day and more!

Volunteer

Support AACT

Become a ‘Friend of the Academy’ through a tax-deductible financial contribution. Donating is just a text away!

Make a Contribution
aact-footer-logo

American Academy of Clinical Toxicology
1061 East Main Street, Suite 300
East Dundee, Illinois 60118
847-752-9365

Proudly Managed by
Veritas Logo

LinkedIn Twitter/X Facebook Bluesky

Privacy Policy

  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
    • National Clintox Book Club
    • Webinars
  • NACCT Annual Meeting
    • Abstract Submissions
    • Meeting Information
    • Register
    • After the Fact CE
  • Research Grants
    • AACT Research Award
    • AACT Knowledge Translation Grant Award
    • Junior Investigator Research Grant
    • Gary S. Wasserman, DO, FAACT Memorial Pediatric Abstract Award
    • Toxicology Trainee Research Grant
    • Student and Trainee Travel Award
    • Lampe-Kunkel Memorial Award
  • Resources
    • Event Calendar
    • Publications
      • Clinical Toxicology Journal
      • Question of the Day
      • News
      • Current Awareness in Clinical Toxicology
      • Toxicology Today
      • Out of Hospital Guidelines
    • Toxicology Information
    • Affiliated Organizations
    • Press Resources
    • Job Opportunities
    • Online Store
  • About Us
    • Board of Trustees
      • AACT Board of Trustees Nominations
    • Mission & Strategic Plan
    • Bylaws
    • AACT Code of Ethics
    • Our History
    • Fellows of AACT
    • Membership
      • AACT Member Directory
    • Award Recipients
    • Contact Us
  • Contact Us

© 2025 American Academy of Clinical Toxicology | Sitemap

Website by Yoko Co

Scroll To Top