What medication has been applied topically to the site of an esophageal stricture in order to improve the outcome of those requiring endoscopic dilation caused by the ingestion of a caustic agent?
Mitomycin C applied topically at the time of dilation has been shown to decrease the need for future dilations.
El-Asmar KM, Hassan MA, Abdelkader HM, Hamza AF. Topical mitomycin C application is effective in management of localized caustic esophageal stricture: a double-blinded, randomized, placebo-controlled trial. J Pediatr Surg. 2013 Jul;48(7):1621-7. doi: 10.1016/j.jpedsurg.2013.04.014. PMID: 23895984.
Contributed by: Bruce Ruck, PharmD, BS