Question - What mechanisms have been proposed to account for an association between cannabis smoking and the development of acute coronary syndrome?
Answer - The cited article notes “Cannabis smoking can result in elevation of heart rate and blood pressure immediately after se, possibly from sympathetic nervous system stimulation and parasympathetic nervous system inhibition. Vascular inflammation, platelet activation and carboxyhemoglobin n generation have also been proposed as potential side effects of a cannabis smoking. As such, an association between cannabis use and acute coronary syndrome has been postulated.” (Richards JR at al. Cannabis use and acute coronary syndrome. 2019 Clin Tox 57(10):831-841)