What is Lhermitte’s sign, and what toxin induced clinical syndrome is it associated with?
Lhermitte’s sign is a clinical finding associated with flexion of the head resulting in a shower of parasthesia sensation through the upper and lower extremities. It is typically associated with multiple sclerosis, but has also been described in chronic nitrous oxide abuse.
Blanco G, Peters HA. Myeloneuropathy and Macrocytosis Associated With Nitrous Oxide Abuse. Arch Neurol. 1983;40(7):416–418. doi:10.1001/archneur.1983.04050070046009