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April 6, 2021

Question of the Day – Tuesday April 6, 2021

When did cardiac arrest or sudden unexpected deaths occur following intramuscular injection of long-acting paliperidone palmitate?

10-14 days after injection of the one-month formulation or 11-24 days after injection of the three-month formulation. A review of 473 adverse drug reactions reported to the French pharmacovigilance database identified 27 cases of cardiac arrest or sudden unexpected death. These time frames correlate to expected timing of peak concentrations after injection and occurred most commonly within the first 6 months of treatment.

Boels D, et al. Fatal and life-threatening ADRs associated with paliperidone palmitate: an observational study in the French pharmacovigilance database. Clin Toxicol (Phila) 2021, DOI: 10.1080/15563650.2021.1878206

 

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
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      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
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    • Student Chapters
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