What observations were made when Danish investigators analyzed data from acetaminophen overdoses before and after a public health initiative that limited the package size of acetaminophen products to a max of 10 grams?
The authors identified a lower number of paracetamol poisonings, a decreased proportion of poisonings involving ingestion of more than 20 g of paracetamol, and a lower occurrence of hepatotoxicity in association with the new regulation.
Andersen CU, Hansen S, Dalhoff KP, Nielsen LP, Møller JM, Olesen AE. Clinical characteristics of hospitalized patients with paracetamol poisoning before and after restrictions of over-the-counter sale of paracetamol. Clin Toxicol (Phila). 2023 Mar 15:1-6. doi: 10.1080/15563650.2023.2181104. Epub ahead of print. PMID: 36919499.