What specific therapy may augment the treatment of dysrhythmias in chloroquine (and HCQ) overdoses?
Diazepam 2mg/kg IV over 30 mins followed by 2mg/kg/day for 2-4 days (patients may require intubation); epinephrine (or other vasopressors) may be used in conjunction
Riou B, Barriot P, Rimailho A, Baud FJ. Treatment of severe chloroquine poisoning. N Engl J Med. 1988 Jan 7;318(1):1-6. doi: 10.1056/NEJM198801073180101. PMID: 3336379. de Olano J, Howland MA, Su MK, Hoffman RS, Biary R. Toxicokinetics of hydroxychloroquine following a massive overdose. Am J Emerg Med. 2019 Dec;37(12):2264.e5-2264.e8. doi: 10.1016/j.ajem.2019.158387. Epub 2019 Aug 6. PMID: 31477360
Contributed by: Toxikon Fellowship
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